Have you tried this in a small scale setup, with just a few VMs in an isolated network?
I'm trying to understand how will the replicated VMs have a view of the DNS which is different than that of production or is it the same.
Ideally, if things resolve it should not be a problem theoretically. If the MAs are the same the data paths won't change for the clients so it should work.
The other thing to consider is if/when/how the site goes down if you're using dedupe, to consider that recovery time into the DR scenario as well.